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( E J ) Primary RTECs from Rest fl/fl mice were infected with control or Ad-Cre-GFP and cotransfected with control or siRNAs against GCLM ( siGCLM ) ( E ), and then subjected to HR injury for analysis of GCL activity ( F ), Western blot analyses of ferroptosis-related proteins REST, GCLM, GPX4, ACSL4, GCLC, FSP1, and DHFR ( G ), GSH levels ( H ), MDA levels ( I ), and TEM observation of ferroptosis ( J ) ( n = 3)

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These findings suggest that Homocysteine does not cause direct neurotoxicity but enhance the sensitivity of dopaminergic neurons to the environmental toxins

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Zhang J., Liang L., Miao X., Wu S., Cao J., Tao B., Mao Q., Mo K., Xiong M., Lutz B.M., et al

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