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GAT1 also clears GABA from the extracellular space

Aging further exacerbates vulnerability: in aged or overweight mice, reduced basal NRF2 antioxidant capacity and diminished mitochondrial reserve in aged or overweight mice lead to exaggerated ROS surges and excessive UPR activation during I/R (120), whereas short-term fasting reinduces NRF2, lessens acute necrosis, and mitigates BUN elevation in these models, consistent with metabolic reprogramming as a protective mechanism

They kind of hit a bunch of articles and give you an update on what they found, but very general, very vague

2024;16(8):e67459

doi: 10.1007/s40200-020-00518-z 171 AkhbariMJabbariMAyatiMHNamaziN

doi: 10.1590/S0100-40422005000600019 57 Cceres-JensenLGanJBezMFuentesREscudeyM