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There's also data suggesting that in some cases, people who take GLP-1s for several years can start to experience a waning effect - perhaps a drug resistance - where they start to regain some weight, even while taking the medication

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At week 13, significant reductions versus placebo were observed in glycated hemoglobin (HbA1c: 0.87%), body weight (2.54%), systolic blood pressure (SBP: 3.84 mmHg), pulse pressure (3.81 mmHg), high-sensitivity C-reactive protein (hsCRP: 18.08%), and lipid parameters including total cholesterol (7.00%), nonHDL-C (8.02%), and triglycerides (8.15%)

This study included 41 participants (RYGB: n=21, OAGB: n=20) from the randomized RYSA trial with similar amounts of bypassed intestine between the procedures

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