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For UC patients who also struggle with obesity or diabetes, these medications might offer dual benefits by addressing these comorbidities while potentially reducing inflammation

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Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

The first generation of weight loss drugs focused on stimulant effects or blocking fat absorption, approaches that produced modest results with significant side effects and safety concerns

Supplementary Materials Data Availability Statement The raw data supporting the conclusions of this article will be made available by the authors on request.

43 Recently, an informatics approach combined with detailed human heart single cell resolution data highlighted pacemaker cells as cellular targets for GLP-1 analogues