phentermine vs glp-1 Weight-Loss Medication Side Effects and How to Manage Them Understanding Weight Loss Medications: GLP-1

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An increased risk of NAFLD (Non-alcoholic fatty liver disease) is seen in obese patients, with annual burdens in the treatment of NAFLD estimated to be in the hundreds of billions for the US [10]

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This dual GLP-1/GIP receptor agonist demonstrated weight loss of up to 22.5% in clinical trialssubstantially greater than monotherapy GLP-1 agents

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This process occurs in the intestinal L cells of the gastrointestinal tract leading to the co-secretion of GLP-1 and oxyntomodulin in response to nutrient sensing ( Figure 1 Whilst much attention was focused on GLP-1 in the 1980s and 90s, following the discovery of its incretin effect in humans (39), suggesting that OXM may act through the GLP-1 receptor (GLP-1R) to regulate food intake