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62 In the fourth edition of The principles and practice of medicine , published in 1901, the Canadian physician and Regius Professor of Medicine at Oxford, William Osler, highlighted the pivotal role of smoking and fumigating as both therapeutic and prophylactic: The sedative antispasmodics, such as belladonna, henbane, stramonium, and lobelia, may be given in solution or used in the form of cigarettes

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First, your brain develops an excess of nicotine receptors that need more and more nicotine to be stimulated

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