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Glutamine also functions as both a carbon and nitrogen donor for the synthesis of reduced glutathione (GSH) by providing glutamate and enabling cysteine uptake (Wu et al., 2004

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For instance, miR-21 promotes CD4 + T cell glycolysis through the PTEN/PI3K/AKT pathway, which increases the cell cycle, promotes CD4 + T cell polarization toward the Th2 phenotype, and releases the fibrogenic cytokine IL-13, which is involved in arsenite-induced hepatic fibrosis [110] (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Meng X., Zhang G., Cao H., Yu D., Fang X., Vos W.M., Wu H