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That's a meaningful distinction when you consider what happens the moment you stop using the drug and blood flow returns to normal

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Epigenetic Regulation NNMT activity consumes S-adenosylmethionine (SAM), the universal methyl donor required for hundreds of methylation reactions throughout the cell

It may be relevant as a potent cytoprotective agent with strong vascular rescuing capabilities [1,2,3,4,5,6,7,8,9,10] as a novel cytoprotective approach in glaucoma therapy [11]