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This may be attributed to the role of metformin in reducing the production of sFlt-1 and soluble endoglin by endothelial cells, trophoblasts, and syncytiotrophoblasts, and modulating anti-angiogenic factors at the mitochondrial level (Romero et al., 2017)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.de Wet TJ, Winkler KR, Mhlanga M, Mizrahi V, Warner DF

Peptide therapy has emerged as a promising solution to help alleviate these symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] [50].Zaldivar-Machorro VJ, Lopez-Ortiz M, Demare P, Regla I, Munoz-Clares RA