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First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor

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This can lead to cellular and tissue damage, contributing to aging and the development of various diseases, including: Cancer Cardiovascular diseases Neurodegenerative disorders (such as Alzheimers and Parkinsons diseases) Diabetes Chronic fatigue syndrome Inflammatory conditions Free Radicals Free radicals are generated through normal metabolic processes, such as cellular respiration, as well as from external sources like pollution, radiation, cigarette smoke, and certain chemicals

Caspase 1 (CASP1), when activated, cleaves gasdermin D (GSDMD), producing the pore-forming protein N-GSDMD, and also cleaves pro-IL1B and pro-IL18 into their mature forms [138]