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Oxidative DNA stress occurring after cerebral ischemia is associated with a decrease in apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) expression (Fujimura et al., 1999)
PMID: 149 Rodriguez-CarrioJLopezPSanchezBGonzalezSGueimondeMMargollesAet al

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Ji X, Dong X, Li J et al (2025) Fisetin clears senescent cells through the Pi3k-Akt-Bcl-2/Bcl-xl pathway to alleviate diabetic aortic aging

In cases where patients exhibit symptoms beyond standard diabetic concerns or face medication limitations, a seamless referral system to specialists is crucial
