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The group of Gary Yellen elegantly showed that both BHB and AcAc reduce firing rates in neurons of the dentate gyrus by favoring the opening state of the potassium ATP-sensitive (K-ATP) channels, which can be blocked by intracellular ATP (Ma et al., 2007)

In another in vitro experiment where ketones were the sole energy source for cardiomyocytes, acute contractile dysfunction was observed

Skeletal muscles make up 98% of the bodys carnitine pool, which is sustained through the absorption of L-carnitine from dietary sources, endogenous biosynthesis, and efficient renal tubular reabsorption [19]

Metabolic and signaling roles of ketone bodies in health and disease

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