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Fatigue, for example, has dozens of causes

The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light

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TB-500 has a half-life of approximately 710 days, meaning plasma levels remain detectable for 34 weeks after a single injection