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Practical Neurology

Initially, the mechanisms of action of this enzyme were considered paradoxical because CD38 is predominantly localized on the cell surface, yet its final products are utilized within cytoplasmic compartments

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Hogan, K

What that means isnt always straightforward: In the Swiss study mentioned above, nearly three-quarters of primary-care docs surveyed reported using a multi-step approach (and not always the same one) when testing for B12 deficiencya practice that Miller says improves the odds of an accurate diagnosis since serum B12 levels alone dont always accurately identify a deficiency