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Protein misfolding and aggregation underlie major neurodegenerative diseases such as Alzheimers (AD), Parkinsons, and Huntingtons disease, further characterised by neuronal loss, mitochondrial dysfunction, toxic fibril formation, and oxidative stress

This controlled inflammatory environment favors repair over destruction

Glassock RJ, Winearls C

For someone in a caloric deficit targeting fat loss, that hunger response undermines the entire protocol

In both BDL and lithocholic acid-treated Huh-7 cells, the fall in expression of GSH synthetic enzymes coincided with an increase in the expression of several Maf proteins (c-Maf, MafG and MafK) as well as increased c-Maf and MafG nuclear binding to ARE
