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Testing of lesional tissue (neurofibromas, caf-au-lait macules) is available and is of particular use in these patients

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The hydrophobicity index of the AEDG peptide was calculated according to the Kite-Dullit table as the sum of the hydrophobicity index of each amino acid residue included in the peptide

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The magic happens at a cellular level

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10.1016/j.tips.2023.08.012 395 ScheltensP.De StrooperB.KivipeltoM.HolstegeH.ChtelatG.TeunissenC

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In the APP/PS1 mouse model of AD, administration of AKG or calcium -ketoglutarate (Ca-AKG) ameliorated impaired long-term potentiation at hippocampal CA1 synapses, with more pronounced effects observed in female AD mice

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