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This is largely due to the unique biological and clinical characteristics of GB, including dynamic evaluation of the tumor, its highly heterogeneous tumor microenvironment, and poor drug penetration through BBB, as illustrated in Figure 3
10.1136/jnnp.2004.047829 44 CortiO.HampeC.DariosF.IbanezP.RubergM.BriceA.et al
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Long term (weeks 812): Consistency completely dominates timing
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