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Description
HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia

Deficiency leads to methylmalonic acid accumulation, which may incorporate abnormal fatty acids into myelin, further compromising nerve function

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Aberrant activation of Drp1 disrupts mitochondrial homeostasis, thereby triggering NLRP3 inflammasome activation and caspase-3 cleavage, which in turn amplify neuroinflammatory cascades (Sbai et al., 2023)
The expression and activity of these NAD+-consuming enzymes have been found to increase with age meaning that the demand for NAD+ also increases

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