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In addition, glutamine-derived -KG is oxidized to succinate and fumarate, which maintain the TCA cycle in cancer cells by providing ATP, NADH, and FADH 2 and by acting as oncometabolites 22

Saadat I, Shakibaie M, Jomehzadeh A, Salimi A, Rahimi HR, Torabizadeh SA

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Dietary Methyl Donors, Epigenetic Alterations, and Stress-Related Disorders Studies have shown that early life experiences cause a developmental programming of the hypothalamicpituitaryadrenal (HPA) axis or stress axis and behavioral responses to stressors [17,77,78]