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NRF2 deficiency replicates transcriptomic changes in alzheimers patients and worsens APP and TAU pathology

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Identification of orthologs and phylogenomic analysis To compare gene content and conservation, we identified orthologous gene clusters in these sequenced genomes and in other Onygenales genomes using OrthoMCL (version 1.4) with a Markov inflation index of 1.5 and a maximum e-value of 1e-5 49

Escobar, A., Gaete, V

341 The recognition triggers the PRR to oligomerize and associate with a complex comprising adaptor proteins and effector enzymes