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*Correspondence: Yilei Mao, [email protected]

10.1002/jsfa.9210 264 MuralidarS.AmbiS

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Because the mitochondrial inner membrane is exposed to an oxidant abundant environment and consists of high levels of cardiolipin, a LA-rich membrane lipid when dietary LA is high, 687 it is not surprising that linoleate oxidation products including HODEs, DiHOMEs, TriHOMEs, oxo-OMEs, oxo-EpOMEs, HpODEs and Hp-oxo-OMEs are constitutive members of the mitochondrial lipidome

However, as essential as most of them are to body function and homeostasis, overactivation of GPCRs has been implicated in many pathologic diseases such as cancer, asthma, and heart failure (HF)

Double board-certified, American Board of Plastic Surgery and American Board of Surgery