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Drug development for nose-to-brain delivery for migraine Migraine is an episodic form of chronic headache that occurs in attacks, often accompanied by nausea and vomiting

Available from: [DOI] [PubMed] [Google Scholar] 16.Williams SF, Alvarez JR, Pedro HF, Apuzzio JJ

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Biosci Biotechnol Biochem 61:13791381

Because the gland stays in control, the body's feedback loops keep regulating output instead of being bypassed

no LD50 established even at very high doses in rodents No Hormonal Effects: Does not affect testosterone, estrogen, growth hormone, or other hormonal axes Gastric Origin: Derived from a naturally occurring human gastric protein, suggesting good biological compatibility Stability: Unusually stable in gastric acid, supporting oral administration potential Reported Effects: Anecdotal reports of fatigue, nausea in some research subjects TB-500 Safety Profile: (PMID: 20536472) Note: Published safety data is primarily available for Thymosin Beta-4