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We thank Gong-Min Lin at Metabolomics Core Facility of Agricultural Biotechnology Research Center in Academia Sinica for the assistance of metabolomics analysis and 13 C metabolite tracing

Menoufia Med J

As expected, the chemically reactive metabolites were much more cytotoxic than their respective precursors and displayed comparable and steep dose-dependent decreases in cell viability ( Figure 2 )

Furthermore, they had a 94.6% higher glutathione concentration in their red blood cells, which also led to no statistical difference between the young controls and the elderly subjects in their glutathione levels

Chronic inflammation increases reactive oxygen species, damaging organ structure and function

Glutathione is the bodys primary antioxidant and is involved in immune function, liver detoxification, cellular repair, inflammation regulation, and energy metabolism