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Indeed, other tissues from the Gclc KO mice, including the kidney, pancreas, and spleen, were also histologically similar to tissues from the Gclc WT mice (Fig

This complexity suggests that combinatorial interventions targeting multiple death pathway nodes synergistically may more effectively disrupt the death-resistant barriers of leukemia cells, thereby opening multidimensional attack pathways to overcome therapeutic bottlenecks caused by AML clonal evolution and microenvironmental sheltering (18)

[Google Scholar] 217.Comen E.A., Bowman R.L., Kleppe M

Vaughn AR, Branum A, Sivamani RK