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Studies with congenitally leptin-deficient, severely obese subjects revealed that administration of physiological doses of leptin decreased food intake and body weight (7)

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Safety, Tolerability, and Regulatory Perspective Multiple non-clinical toxicology programs and clinical studies have evaluated the safety of AOD 9604: A comprehensive non-clinical dossier reported no evidence of genotoxicity or major toxicological concerns across a range of pharmacokinetic and toxicity studies, supporting a favorable safety profile in standard preclinical models

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