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Feces from donor mice treated with metformin were transplanted into recipient mice, and results showed altered gut microbiota and improved glucose tolerance in the recipient mice ( / mice are adjusted, short-chain fatty acids are up-regulated, and the degree of AS is mitigated after 12 weeks of metformin intervention ( Resveratrol, a non-flavonoid polyphenolic organic compound, is now used as a drug, with studies showing that it attenuates TMAO-induced AS by lowering TMAO levels and increasing hepatic bile acid synthesis via remodeling the gut microbiota ( Traditional Chinese Medicine Progressively more studies are revealing that effective ingredients of Chinese medicines, such as Berberine ( Shi et al