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*Correspondence: Plcido Navas [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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41 , in which RJ exhibited a strong inhibitory effect on Nos2, Il1 , and Tnf mRNA generation by suppressing the activity of NF-B

10.1016/S0899-9007(02)00839-0 163

As expected, the 21mer S tail backbone amide protons of residues nearest in sequence to the spin label were paramagnetically broadened with decreased peak intensities in the oxidized state 64

Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L)