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Glycine inhibits the LPS-induced increase in cytosolic Ca2+ concentration and TNFalpha production in cardiomyocytes by activating a glycine receptor

Multiple other cell types throughout the central and peripheral autonomic nervous system are also involved, probably from early disease onwards

It supports the integrity of brain cell membranes, facilitates communication between neurons, and helps combat neuroinflammation, which is a key driver of age-related cognitive impairment

While considered reliable and straightforward, most of the experimental assays are labor intensive and are impractical to implement with a large number of mAb candidates

Am J Physiol Cell Physiol 287(4):C817C833