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Description

10.1038/s41467-018-07953-w 136 Silva BritoR.CanedoA.FariasD.RochaT

Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy

A fed-batch fermentation experiment was performed on strain E

A., & Al-Gareeb, A

Methods The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 g/kg) (12 ml/rat/day) or intraperitoneally (10 g/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery