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SYK deficiency impaired the core mitophagy machinery, evidenced by reduced levels of PINK1(the sensor of mitochondrial damage) and Parkin (the E3 ubiquitin ligase that ubiquitinates mitochondria for degradation)

23, 27 Vitamin B 12 Early treatment of B 12 deficiency is particularly important because neurologic symptoms may be irreversible

PMC 10879199

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However, our study has limitations, as the cell damage caused by H 2 O 2 may not fully mimic the complex pathological conditions observed in humans, which requires further exploration

Doctors here (state of Maryland, USA) are required to follow the standard of carenot just for PA, but for any condition that has an established standard of care