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Our guide to tirzepatide with methylcobalamin covers this distinction in depth, and our cyanocobalamin tirzepatide guide covers the more common formulation

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Mol Cell Biol 14(9):58325839

Theprincipal distinction between methyl-, ethyl-, andn-propyl-cobalamin lies in the relative stability of this MLCT state, with the terminal alkyl groups in ethyl and n-propyl acting as electron donors to destabilize the partial carbon anion in the MLCT state

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doi: 10.1016/s0140-6736(63)91500-9