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At doses that are above the safe maximum level (overdose), opioids can cause extremely slow breathing, reducing the amount of oxygen getting to the brain below the amount needed to stay alive and causing death

5UTR of the neurogenic bHLH Nex1 / MATH-2 / NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites

In some cases, the production of acetaldehyde is insufficient

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Peptide therapy may not be appropriate for everyone