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Multimodal discrimination of schizophrenia using hybrid weighted feature concatenation of brain functional connectivity and anatomical features with an extreme learning machine

Recent studies identify a mechanistic link between a Western diet, gut microbiotadependent metabolism, and development of both cardiovascular disease (CVD) and metabolic diseases (13)

There is a lack of randomized, double-blinded, placebo-controlled studies

The Kat6a null allele was generated as described previously, with the deletion of 5 exons (exons 48 of 17 exons in NM_001364449.1 and exons 59 of 18 exons in NM_001081149.2) resulting in a premature stop codon in the catalytic domain (Voss et al, 2009)

PMID: 37592347 Aging Cell 2026 Apr;25(4):e70451

Abbreviations AASLD: American Association for the Study of Liver Diseases CGA-HE: Clinical Global Assessment of Hepatic Encephalopathy CI: confidence interval EASL: European Association for the Study of the Liver FMT: fecal microbiota transplantation GABA: gamma aminobutyric acid GPB: glycerol phenylbutyrate HAS: hepatic encephalopathy scoring algorithm HE: hepatic encephalopathy HR: hazard ratio LOLA: L-ornithine L-aspartate NAD: non-absorbable disaccharides NNT: number needed to treat OR: odds ratio PAA: phenylacetic acid PBA: phenylbutyric acid PEG: polyethylene glycol PHES: Psychometric HE-score RBANS: Repeatable Battery for the Assessment of Neuropsychological Status RCT: randomized clinical trial RR: relative risk SCFA: short-chain fatty acid SOC: standard of care TIPS: transjugular intrahepatic portosystemic shunt WHS: West Haven scale Declarations Acknowledgement This work was made possible by the Herman Lopata Chair in Hepatitis Research