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Grate G, Toriello M, Gonzlez-Quintanilla V, et al

C., Rimm E

Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results

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Postoperative pathological results showed an extramural rectal tumor with necrosis and significant desmoplasia, while IHC showed PAX-8 (+), PAX-2 (), CK7 (+), CK20 (), CK5/6 (), CDX-2 (), GATA-3 (), Calretinin (), D2-40 (), WT-1 (), GCDFP-15 (), AR (), ER (minimal, +), NapsinA (), and Ki-67 (+) in about 30%, which was consistent with metastatic adenocarcinoma and liver tumor with diffuse necrosis ( Figure 4 )