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Animal experiments have shown that: Inhibition of NMDA receptor overactivation: DSIP injection (60 nmol/kg, intraperitoneal) significantly reduced c-Fos expression in the paraventricular nucleus (PVN) of the hypothalamus induced by restraint stress

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Contrary to the intuitive expectation that a larger or more rigid group directly interacts with the macrocycle to affect the dethreading rate, our findings indicate that the rate modulation arises from conformational changes induced by the stopper substituents