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Although the direct connection between hypertension and TMAO has not yet been fully established, it is known that it prolongs the hypertensive effect of angiotensin II and determines an increase of vascular inflammation and a direct prothrombotic effect by the promotion of platelet hyper-responsiveness to multiple agonists both in humans and rodents (133, 134)

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Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

But it is just that: an assumption, added Dr Pacey, who was not part of the research team