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Profiles of Drug Substances, Excipients and Related Methodology (2023)

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6PR and Supplementary Fig

Its cytotoxic mode of action is mediated by its interaction with DNA to form DNA adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways, including those involving ATR, p53, p73, and MAPK, and culminate in the activation of apoptosis

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Delivery of epitopes by the Salmonella type III secretion system for vaccine development