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However, there is controversy as to the reliability of serum GHBP level as a marker of GH receptor levels in specific tissues [13]

Cutting edge: a hypomorphic mutation in Ig (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development

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Endogenous (e.g., inflammation) and exogenous (e.g., diet components, toxicants, or drugs) factors can increase intestinal permeability and cause the formation of a so-called leaky gut. The latter is characterized by the penetration of food antigens, commensals, or pathogenic bacteria into the blood, causing the development of inflammation (Vanuytsel et al., 2021)

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