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If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
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Although the progression of neurologic complications is generally gradual, such symptoms may not be reversed with treatment of vitamin B 12 deficiency, especially if they have been present for a long time
The addition of IMiDs for patients with daratumumab-refractory multiple myeloma can overcome refractoriness to both agents
