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and Cynthia Gibsons Participatory Grantmaking, produced for the Ford Foundation

10.1152/ajpendo.00050.2011 154 WilliamsA

doi: 10.1056/NEJM199902113400607

GIPR agonism could exert beneficial metabolic effects by enhancing glucose-stimulated insulin secretion, increasing postprandial adipose tissue blood flow and triglyceride storage, and by attenuating weight loss-induced bone loss by decreasing bone resorption and increasing osteoblast activity

With a 3.33mg/mL concentration, losing 1 unit of dead space per injection wastes about 0.033mg per dose

Additionally, gastrointestinal side effects including nausea, vomiting, and diarrhoeaare common with GLP-1 medications and can contribute to tiredness through dehydration and reduced food intake