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A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides

Further SAR studies showed that special disposition of basic nitrogen atom at the 7-position was important to exert high PDE5 inhibition and specificity, with optimized methylpicolyl group as in 11 reaching -40-fold selectivity over PDE6 (IC50 = 0.22 nM) [58]

thaliana [60, 61]

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A characteristic occipital epileptiform EEG pattern in ADCK3-related mitochondrial disease