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Proposed mechanisms include oxidative stress, mitochondrial dysfunction, dyslipidaemia, and genomic modulation of hypertrophic and fibrotic signalling pathways (70)

Published 2017 May 5

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Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and fyn

[15] [16] [18] Although TEDspecific bone mineral density data for IV pulse regimens are limited, systemic glucocorticoid exposure in general is associated with increased fracture risk, and patients at elevated risk should be managed according to glucocorticoidinduced osteoporosis guidelines

This research has increased interest in nutritional approaches designed to provide key building blocks needed for glutathione synthesis