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The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting

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Wade Lightheart: Yeah, it's amazing that, you know, of course there was an incredible amount of psychedelic research early in the sixties, and then that all got kaboshed after the kind of Tim Leary, Ram Dass splits were kind of going around and getting, you know, drop in, drop it, which was really a lot of unregulated experimentation