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Additionally, some cells, mostly in the liver, can synthesize NAD + de novo from multiple dietary sources

[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Bruzzone, S., Guida, L., Zocchi, E., Franco, L

This early mechanistic work provided the rationale for moving AOD9604 into human clinical trials

The safety database, while extensive for clinical trials, represents limited duration and population diversity compared to the variability encountered in clinical practice
