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no separate PDA trial base as of April 2026

Despite advances in immunotherapy and targeted therapies, treatment resistance and recurrence persist due to the genetic heterogeneity of HCC and the scarcity of actionable driver mutations

Step 3: If TS 45%, perform HFE gene testing

Cohen SA, Aushev VN, Laliotis G, Jabbal IS, Nagarajan A, Wang C, Fakih M, Sharif S, Alyunis F, Tejani MA, Alqahtani A, Marshall J, Chang J, Botta G, Manage K, George GV, Sharma S, Malhotra M, Chandana S, Mehler S, Somer BG, Babadi E, Wu C, Hanna D, Chidharla A, Kasi A, Vosoughi E, Dayyani F, Pedersen K, Briski RE, Azzi G, Katiyar V, Chan A, Sharma V, Shreenivas A, Chakrabarti S, Fuqua J, Malla M, Polite B, Bent AH, Rabinowitz M, Jurdi A, Liu MC, Aleshin A, Kopetz S

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Melville DB, Lubschez R (1953) A method for the determination of ergothioneine in blood