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Intriguingly, BVR-A-related unresponsiveness of insulin signaling was associated with the aberrant regulation of downstream pathways such as the mTOR/autophagy axis (412)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Wang J., Tang B., Liu X., Wu X., Wang H., Xu D., Guo Y

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While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas

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