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doi:10.1016/j.jconrel.2016.05.044 54

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296,298 One case report described the benefit of SAMe in a 32 year old patient with anxiety who was found to have a MTHFR gene mutation: treatment with methylated B 12 and folate was not effective for relieving symptoms until SAMe, 400 mg twice daily, was added

A combination can be scientifically interesting and still remain unapproved for human use

One vial produces strong appetite suppression and the next produces almost none

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