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Description
M.GainetdinovR
In the nervous system, phosphorylation homeostasis is particularly important: subtle changes in kinase or phosphatase activity can reorganize cytoskeletal networks, reshape synaptic plasticity, and influence myelination 8, 9
Two reasons are commonly cited: preventing receptor desensitization and avoiding copper accumulation
At the same time, inhibiting NNMT also helps preserve another important molecule: S-Adenosyl Methionine (SAM)
Get it wrong and you have expensive water
A second cycle builds on what the first started
