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The four primary underlying mechanisms can be summarised as follows (Figure 6: First, radiotherapy can upregulate the expression ofataxiatelangiectasia mutated (ATM) gene and further inhibit the transport function of system XCthrough inducing DNA double strand breaks (DBSs), which leads to the inhibition of antioxidant activity of GSH and GPX4, therebyresulting in lipid peroxidation ( FIGURE 6 Regarding the application of ferroptosis in radiotherapy, the combination of radiotherapy and the ferroptosis inducer (FIN) was found to act synergistically in tumour treatment by increasing lipid peroxidation and upregulating PTGS2 expression, with FINS exerting significant radio-sensitising effects in vitro and in vivo ( , leading to GSH depletion ( in vivo , resulting in the improved efficacy of radiotherapy and inhibition of tumour growth ( Furthermore, a study reported that ferroptosis was also involved in radiotherapy-induced cellular damage in normal cells instead of only affecting tumour cells ( Combined Application of Ferroptosis and Photodynamic Therapy Photodynamic therapy (PDT) is a non-invasive cancer treatment modality

High levels can be linked to high iron (possible hemochromatosis) and low levels can be a sign of functional anemia

More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers

In this context, three main routes have been explored: the enhancement of extracellular and intracellular antioxidant defenses, the reduction of oxygen, and the targeted scavenging of harmful biological molecules (Figure 2)

High-fat and high cholesterol diet induces Alzheimers like disease in mice