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Heterozygotes (1 per 500 people) typically exhibit a 30% increase in the duration of skeletal muscle blockade after a standard dose of succinylchloline, whereas homozygotes (1 per 2000 to 5000 people) can experience 2-3 hours of neuromuscular blockade (Thomsen et al, 2015

The accumulation of ROS damages cochlear cells, particularly OHCs, leading to apoptosis and subsequent auditory dysfunction

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Cholic acid and chenodeoxycholic acid, the primary bile acids, are synthesized in the liver

Similarly, paclitaxel binds with -tubulin, the main component of the mitochondrial membrane, and opens the mitochondrial permeability transition pore (mPTP), resulting in a rapid mitochondrial depolarization and cytochrome c release from mitochondria in a neuroblastoma cell line ( in vitro studies, paclitaxel-induced mitochondrial dysfunction significantly hampered cellular respiratory function and ATP production in DRG neurons (Ikegami and Koike, 2003

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